In other cases however cell cycle progression appears to be required for the further differentiation of some cell types there are also examples in which cell cycle and differentiation seem to be controlled at the same level and progress rather independently from each other or are linked by the same regulator or pathway furthermore . The cell cycle during dissolution of pluripotency and cell differentiation g1 phase may provide a window of opportunity for the dissolution of pluripotency as during this phase many developmental genes contain permissive epigenetic marks h3k4me3 and 5 hydroxymethylcytosine cyclin b1 actively prevents pluripotency exit increased expression . Cyclins cyclin dependent kinases and other components of the core cell cycle machinery drive cell division growing evidence indicates that this machinery operates in a distinct fashion in some . Essentially cell proliferation increase in numbers occurs through cell division where a cell divides into two equal copies here growth factors within a given environment employ various growth factor signaling pathways that not only influence promote cell growth but also activate these cells to enter the cell cycle. Cell reports article two distinct e2f transcriptional modules drive cell cycles and differentiation maria c cuitino1 thierry pecot1 daokun sun12 raleigh kladney2 takayuki okano uchida1 neelam shinde3 resham saeed3 antonio j perez castro3 amy webb4 tom liu4 soo in bae2 linda clijsters5 nicholas selner1 vincenzo coppola2 cynthia timmers14 michael c ostrowski1 michele
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